Norotyl LA (Canada)
Norotyl LA (Canada)
This page contains information on Norotyl LA for veterinary use.
The information provided typically includes the following:
Norotyl LA Indications
Warnings and cautions for Norotyl LA
Direction and dosage information for Norotyl LA
This treatment applies to the following species:
Tylosin Injectable Suspension
For Veterinary Use Only
Norotyl LA is a cream coloured suspension for intramuscular administration containing tylosin (Ph. Eur.) 150 mg per mL in a long-acting oily base.
Norotyl LA Indications
Norotyl LA is specifically formulated to provide sustained antibacterial activity following a single administration.
For the treatment of swine pneumonia caused by, or associated with, strains of Pasteurella multocida sensitive to tylosin.
Tylosin is a member of the macrolide group of antibiotics and its pharmacological properties are similar to other members of that group.
Tylosin inhibits prokaryotic protein synthesis by binding to the 50S ribosomal sub-unit, at, or near, the donor site, thereby sterically preventing peptidyl transfer RNA from binding to the donor site. Elongation of the developing peptide chain as the ribosome moves along the mRNA strand requires translocation of the developing peptide chain from the acceptor site to the donor site. By binding to the donor site, tylosin interferes with this translocation step, thereby inhibiting protein synthesis.
The drug is bacteriostatic but at high concentrations it may be bactericidal. The antibacterial spectrum of tylosin is essentially gram-positive, similar to that of penicillin G, although it is generally more active against fastidious gram-negative species.
Following administration of Norotyl LA on a single occasion at the recommended dose rate of 20mg/kg bodyweight there is an early peak plasma level followed by prolonged circulating therapeutic levels of tylosin. As a member of the macrolide group of antibiotics, tylosin characteristically exhibits low plasma levels following parenteral administration with accumulated levels in target tissue which have been reported to be up to 3-4 times the concentrations achieved within serum.
Norotyl LA Dosage And Administration
Norotyl LA may be administered to pigs by the intramuscular route of administration only.
The recommended dose rate is 20 mg tylosin per kg bodyweight, equivalent to 1 mL Norotyl LA per 7.5 kg bodyweight. The maximum dose volume to be injected at any one site is 5 mL. In heavier animals the maximum volume per injection site can be increased to an amount which would allow no more than two injections.
Shake the vial before use.
Norotyl LA Caution
Do not inject intravenously.
A transient slight swelling may occur at the injection site and may take up to 6 days to completely resolve.
Local tissue reaction at the injection site may result in trim loss of edible tissue at slaughter. To reduce the possibility of excess trim at the injection site, it is recommended that pigs not be slaughtered for up to 21 days after the latest treatment with this drug.
Laboratory studies in mice and rats have not produced any evidence of adverse effect on the reproductive system. However, the effects of Norotyl LA on swine reproductive performance have not been determined.
This product does not contain an antimicrobial preservative. Swab the septum with alcoholic spirits before removing each dose. Use a dry, sterile needle and syringe.
Following withdrawal of the first dose the product should be used within 28 days. Discard unused material safely.
For animal treatment only.
The use of tylosin in swine has been associated with transitory adverse reactions of the rectal mucosa, including oedema, mild protrusion, as well as diarrhea, erythema and pruritis.
A transient slight swelling may occur at the injection site which quickly resolves.
Treated swine must not be slaughtered for use in food for at least 14 days after the latest treatment with this drug.
Keep Norotyl LA, and all drugs, out of reach of children.
Store below 25°C and protect from light.
Net contents of 100 mL.
MANUFACTURED BY Norbrook Laboratories Limited, Newry, Co. Down, BT35 6JP, Northern Ireland
DISTRIBUTED BY Walco Canada Animal Health Ltd, 9471-49st, Edmonton, Alberta T6B 2L8 Canada
WALCO CANADA ANIMAL HEALTH
9471-49 ST., EDMONTON, AB, T6B 2L8
Every effort has been made to ensure the accuracy of the Norotyl LA information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the Norotyl LA product label or package insert.
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Typical mistypes for Norotyl LA
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