This page contains information on Metricure for veterinary use.
The information provided typically includes the following:
Warnings and cautions for Metricure
Direction and dosage information for Metricure
This treatment applies to the following species:
Benzathine Cephapirin Uterine Suspension
FOR VETERINARY USE ONLY
Each 19 gram syringe contains 500 mg cephapirin (as benzathine) in emulsifiers (cetomacrogol 1000; emulgin B1) with hydrogenated castor oil as stabilizer in a vehicle of fractionated coconut oil.
Cephapirin, a first generation cephalosporin, is a broad spectrum antibiotic with bactericidal action against sensitive gram-positive bacteria and gram-negative anaerobic bacteria. It is resistant to the action of penicillinase and is active in an anaerobic environment as encountered in an infected uterus. After a single treatment with Metricure, concentrations of cephapirin in endometrial tissue above the MIC of sensitive bacteria are maintained for at least 24 hours.
The suspension is easily infused and is well tolerated, enabling good diffusion of cephapirin into the endometrium.
Metricure is indicated for the treatment of subacute and chronic endometritis in cows caused by Arcanobacterium (Actinomyces) pyogenes, Fusobacterium necrophorum and pigment-forming Bacteroides strains.
To accurately diagnose subacute or chronic endometritis, a vaginoscopic examination should be done to confirm the presence of a discharge from the cervix.
DOSAGE & ADMINISTRATION
Thoroughly clean the vulvar area, maintain aseptic conditions and avoid contaminating the catheter in preparation for the infusion.
Introduce a single dose of 500 mg of cephapirin (one 19 g syringe) into the lumen of the uterus using a disposable catheter. Fix the syringe to the catheter, then taking the cervix into a gloved hand introduced into the rectum; introduce the catheter through the cervix into the lumen of the uterus by gentle oscillating movements of the cervix. Inject the contents of the syringe. Flushing out the catheter is not required.
One treatment is usually sufficient for a complete cure. If the quantity and quality of the cervical discharge is not improved at examination 14 days after treatment, the cow should receive a second treatment. Other contaminating organisms not sensitive to cephapirin may be the cause of the infection and accurate laboratory diagnosis may be necessary. In inseminated animals, Metricure can be used one day following insemination.
Cows could be treated for a second time, 14 days after the first treatment, if the quantity and quality of the uterine discharge is not improved.
In case of anaphylactic reaction administer epinephrine.
Store in a dry place between 15 and 25°C.
Cows treated with a single intrauterine dose of 500 mg of METRICURE INTRAUTERINE SUSPENSION (benzathine cephaprin) must not be slaughtered for use in food for at least 48 hours after the last treatment with this drug.
Cows could be treated a second time, 14 days after the first treatment, if the quantity and quality of the uterine discharge is not improved.
Keep out of reach of children.
No withholding time for milk is required when this product is used in lactating dairy cows according to the label instructions.
Box of 10 syringes with catheters
Box of 12 syringes
Manufactured by: INTERVET INTERNATIONAL B.V, Wim de Körverstraat 35, 5831 AN BOXMEER, THE NETHERLANDS.
Distributed by: INTERVET CANADA LTD.
INTERVET CANADA LTD.
250 WATER STREET, WHITBY, ON, L1N 9T5
877-464-7616 or 800-268-4257
Every effort has been made to ensure the accuracy of the Metricure information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the Metricure product label or package insert.
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