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Cestex* Tablets (12.5 mg)
Cestex* Tablets (12.5 mg) (Canada)
Cestex* Tablets (12.5 mg) (Canada)
This page contains information on Cestex* Tablets (12.5 mg) for veterinary use.
The information provided typically includes the following:
Cestex* Tablets (12.5 mg) Indications
Warnings and cautions for Cestex* Tablets (12.5 mg)
Direction and dosage information for Cestex* Tablets (12.5 mg)
Cestex* Tablets (12.5 Mg)
This treatment applies to the following species:
Cats
Dogs
Manufacturer: Pfizer
Epsiprantel Tablets
DIN 01913034 (12.5 mg), 01913026 (25 mg)
Description
Cestex (epsiprantel) tablets are film-coated and contain 12.5 mg or 25 mg of epsiprantel per tablet. Epsiprantel is an anthelmintic that is highly active as a single dose against the common tapeworms of dogs and cats. Epsiprantel has a molecular weight of 326 and is chemically 2- (cyclohexyl-carbonyl) -4-oxo- 1,2,3,4,6,7,8,12b-octa-hydropyrazinol[2,1-a][2]benzazepine. It is a stable white solid which is sparingly soluble in water.
Action
Epsiprantel acts directly on the tapeworm. Since it is minimally absorbed following oral administration, epsiprantel remains at the site of action within the gastrointestinal tract. Due to the digestive process, tapeworm fragments or proglottides may not be readily visible in the stool.
Cestex* Tablets (12.5 mg) Indications
Cestex tablets are indicated for the removal of tapeworms in dogs (Dipylidium caninum and Taenia pisiformis) and cats (Dipylidium caninum and Taenia taeniaeformis).
Cestex* Tablets (12.5 mg) Dosage And Administration
Cestex tablets should be administered orally. In dogs, the recommended dosage of epsiprantel is 5.5 mg/kg of body weight; in cats, the recommended dosage of epsiprantel is 2.75 mg/kg of body weight. Fasting is not necessary or recommended.
Unless exposure to the infected intermediate hosts is controlled, reinfection is likely and retreatment may be required. In the case of D. caninum, an effective flea control program should be instituted.
Safety
Dogs - The results of a tolerance trial showed that doses up to 100 mg of epsiprantel per kg of body weight (18 times the recommended level) produced no overt toxicity in neither 7- to 10-week-old puppies, nor in adult dogs.
Doses up to 27.5 mg of epsiprantel per kg of body weight (5 times the recommended level) were administered for three consecutive days to 5- to 6-month-old Beagle dogs; and doses up to 16.5 mg of epsiprantel per kg of body weight (3 times the recommended level) were administered for three consecutive days to 7-week-old Beagle and Collie puppies and adult Greyhound dogs. These treatments had no visible effects on clinical signs, hematologic and clinical chemistry values, or gross and microscopic findings at necropsy.
Epsiprantel has also been evaluated in reproductive toxicity studies in breeding and pregnant dogs. There were no adverse effects noted in these studies.
Epsiprantel is not a cholinesterase inhibitor. During the course of clinical field studies, Cestex was administered concurrently with diethylcarbamazine citrate, anti-inflammatory agents, insecticides, and nematocides with no drug incompatibilities noted.
Based on the above results and those of an extensive field trial, it can be concluded that a single oral dose of 5.5 mg of epsiprantel per kg of body weight is safe and efficacious for the removal of Dipylidium caninum and Taenia pisiformis in dogs.
Cats - Doses up to 30 mg of epsiprantel per kg of body weight (≈ 11 times the recommended dosage) produced no overt toxicity in neither 7-week-old kittens, nor in adult cats. Vomiting and trembling were observed in one of 5 kittens given a single dose of 50 mg/kg (≈ 18 times the recommended dosage) and vomiting was observed within a day of treatment in two of 13 cats given a single dose of 100 mg/kg (≈ 36 times the recommended dosage).
Doses up to 13.75 mg of epsiprantel per kg of body weight (5 times the recommended level), administered for three consecutive days to 4- to 5-month-old cats, had no visible effects on clinical signs, hematologic and clinical chemistry values, or gross and microscopic findings at necropsy.
The results of an extensive field trial conducted with 18 investigators in 9 states in the U.S.A., in which a total of 263 evaluable cases were enrolled, confirmed the safety of epsiprantel when administered at the recommended level to cats. During the course of clinical field studies, epsiprantel was administered concurrently with anti-inflammatory agents, insecticides and nematocides with no drug incompatibilities noted.
It is expected from the above data that the recommended level of epsiprantel, administered as a single treatment, will be very well tolerated by dogs and cats.
Warning
Keep out of reach of children.
Cestex* Tablets (12.5 mg) Caution
1. Do not administer to puppies or kittens less than 7 weeks of age.
2. Do not administer to breeding or pregnant cats, as the safety of use in these types of cats has not been determined.
Note
Consult a veterinarian for the diagnosis, treatment and control of parasitism in companion animals.
Storage
Store at temperature between 15 and 30°C.
How Supplied
Cestex epsiprantel tablets are film-coated and contain 12.5 mg or 25 mg of epsiprantel per tablet. Cestex is supplied as described below:
Concentration
Animal Weight Kg
No. Of Tablets Per Bottle
Dogs
Cats
12.5 mg
2.3
4.5
100
25.0 mg
4.5
9.0
100
* Registered trade-mark of Pfizer Products Inc; Pfizer Canada Inc., licensee.
803213.
Pfizer Animal Health, Pfizer Canada Inc., 635 Wilton Grove Road, London, ON N6N 1N7
Nac No.
11980241
PFIZER ANIMAL HEALTH
Pfizer Canada Inc.
17300 TRANS-CANADA HIGHWAY, KIRKLAND, QC, H9J 2M5
Order Desk:
800-663-8888
Toll-Free:
877-633-2001
Technical Services Canada:
800-461-0917
Technical Services USA:
800-366-5288
Website:
www.pfizer.ca
Every effort has been made to ensure the accuracy of the Cestex* Tablets (12.5 mg) information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the Cestex* Tablets (12.5 mg) product label or package insert.
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