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Acemannan Immunostimulant
Acemannan Immunostimulant
This page contains information on Acemannan Immunostimulant for veterinary use.
The information provided typically includes the following:
Acemannan Immunostimulant Indications
Warnings and cautions for Acemannan Immunostimulant
Direction and dosage information for Acemannan Immunostimulant
Acemannan Immunostimulant
This treatment applies to the following species:
Cats
Dogs
Manufacturer: V.P.L.
U.s. Vet. Lic. No.
384
Description
ACEMANNAN IMMUNOSTIMULANT consists of long-chain polydispersed β-(1,4)-linked mannan polymers interspersed with O-acetyl groups. This product is prepared in a lyophilized form. Reconstitution in normal saline produces a solution for intraperitoneal and intralesional injection.
Acemannan Immunostimulant Indications
ACEMANNAN IMMUNOSTIMULANT is indicated for use in the dog and cat as an aid in treatment (i.e. surgery) and clinical management of fibrosarcoma.
Acemannan Immunostimulant Dosage And Administration
Prior to use, reconstitute ACEMANNAN IMMUNOSTIMULANT with 10 mL sterile diluent. Five to 10 minutes may be necessary for complete dissolution. Shake well before using. Use within 4 hours after rehydration.
ACEMANNAN IMMUNOSTIMULANT is administered by concurrent intraperitoneal (IP) and intralesional injections weekly for a minimum of 6 treatments. Recommended IP dose is 1 mg/kg. Recommended intralesional dose is 2 mg injected deep into each tumor mass.
When ACEMANNAN IMMUNOSTIMULANT is used as a prelude to surgery, give concurrent IP and intralesional injections weekly. Continue until delineation, necrosis or maximum tumor enlargement due to edema and immune cellular infiltration occur. Rapid necrosis, which accompanies this response, may happen within 2 to 4 weeks. Surgical excision is recommended immediately upon delineation, necrosis or maximum tumor enlargement.
Benefits of long-term post-surgery treatment have not been clinically established, however, no tumor regrowth has been observed in 5 animals treated with monthly IP injections of 1 mg/kg for 6 months following surgery.
Contraindication(s)
There are no known contraindications for use of acemannan.
Precaution(s)
Do not store over 35°C. Protect from extremes of heat or light.
Acemannan Immunostimulant Caution(s)
The effects of this compound have not been studied in pregnant animals. However, the chemical nature of acemannan and the absence of significant toxicity in several animal species suggest the compound is not a teratogen.
Trial Data
Acemannan is a potent stimulator of macrophage activity. It has been shown to increase TNF-α and IL-1 production in animals. A study was done in 9 dogs and 9 cats with histopathologically confirmed fibrosarcoma. Animals were treated with intraperitoneal and intralesional injections. Eleven of the 18 had surgery in addition to immunotherapy. Twelve of the 18 showed gross tumor necrosis.
Twelve had tumors that increased in size - usually very rapidly (2-4 weeks). This rapid increase suggests an effect attributable to TNF-α. Lymphocytic infiltration and tumor encapsulation were also seen. Benefits of long-term treatment have not been clinically established, however, no tumor regrowth has been observed in 5 animals treated with monthly IP injections of 1 mg/kg for 6 months following surgery.
Manufactured By
Carrington Laboratories, Inc.
Presentation
ACEMANNAN IMMUNOSTIMULANT is supplied in kit form. Each kit contains four 10 mg vials of lyophilized acemannan and four 10 mL vial of sterile normal saline diluent for reconstitution.
Nac No.
11430001
VETERINARY PRODUCTS LABORATORIES
301 W. OSBORN, PHOENIX, AZ, 85013
Telephone:
800-720-0032
Order Desk:
800-720-0032
Fax:
800-215-5875
Toll-Free:
888-241-9545
Website:
www.vpl.com
Email:
info@vpl.com
Every effort has been made to ensure the accuracy of the Acemannan Immunostimulant information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the Acemannan Immunostimulant product label or package insert.
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